Under what condition can the quantity of controlled substances in Schedule III-V be estimated for records?

The correct condition for estimating the quantity of controlled substances in Schedules III-V for records is when the container holds 1,000 or fewer tablets or capsules. This regulation allows pharmacists and practitioners to simplify their record-keeping when dealing with a manageable amount of a substance. The rationale behind this guideline is based on the practicality of handling these medications. For smaller quantities, counting each individual tablet or capsule may not be efficient, especially in busy practice settings. By permitting an estimation for quantities that fall under this threshold, record-keeping becomes less cumbersome while still maintaining a level of accountability for controlled substances.

Choosing a higher limit, such as anything above 1,000 tablets or capsules, would compromise the safe oversight of controlled substances, making it more challenging to track potential misuse or discrepancies. Similarly, the other options related to smaller or specific conditions do not align with the established regulations. Requirements such as not exceeding a certain percentage of the total inventory or having sealed containers do not provide enough context to justify estimating quantities in the same way.