What is considered a significant loss according to the CSA regulations?

The definition of a significant loss in the context of the Controlled Substances Act (CSA) is indeed somewhat subjective and can vary based on the circumstances and the judgment of the registrant. The regulations do not provide a specific numerical threshold or a rigid criterion for what constitutes a significant loss. Instead, they emphasize that registrants are expected to evaluate the situation based on their professional judgment and the context in which the loss occurred.

This flexible approach allows for consideration of various factors such as the type of controlled substance lost, the context of the loss, potential for abuse, and the overall impact on public health and safety. As such, while options that suggest specific monetary values or scenarios may seem concrete, they do not align as closely with the regulatory intent outlined in the CSA. The goal is to ensure that registrants take responsible actions in reporting and managing any losses of controlled substances, regardless of a set dollar amount or specific situation.